Cross-feeding of a toxic metabolite in a synthetic lignocellulose-degrading microbial community.
Lee JA, Baugh AC, Shevalier NJ, Strand B, Stolyar S, Marx CJ. Cross-feeding of a toxic metabolite in a synthetic lignocellulose-degrading microbial community. Microorganisms. 9:321 (2021). doi.org/10.3390/microorganisms9020321
Global transcriptional response of Methylorubrum extorquens to formaldehyde stress expands the role of EfgA and is distinct from antibiotic translational inhibition.
*Bazurto, JV, *Riazi S, D’Alton S, Deatherage DE, Bruger EL, Barrick JE, Marx CJ. Global transcriptional response of Methylorubrum extorquens to formaldehyde stress expands the role of EfgA and is distinct from antibiotic translational inhibition. Microorganisms. 9:347 (2021). doi.org/10.3390/microorganisms9020347
Formaldehyde-responsive proteins, TtmR and EfgA, reveal a tradeoff between formaldehyde resistance and efficient transition to methylotrophy in Methylorubrum extorquens.
Bazurto JV, Bruger EL, Lee JA, Lambert LB, Marx CJ. Formaldehyde-responsive proteins, TtmR and EfgA, reveal a tradeoff between formaldehyde resistance and efficient transition to methylotrophy in Methylorubrum extorquens. Journal of Bacteriology. 203:e00589-20 (2021). doi.org10.1128/JB.00589-20
EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehyde.
Bazurto JV, Nayak DD, Ticak T, Davlieva M, Lee JA, Hellenbrand CN, Lambert LB, Benski OJ, Quates CJ, Johnson JL, Patel, JS, Ytreberg FM, Shamoo Y, Marx CJ. EfgA is a conserved formaldehyde sensor that leads to bacterial growth arrest in response to elevated formaldehyde. PLOS Biology. 19:e3001208 (2021). [pdf] doi.org/10.1371/journal.pbio.3001208
Genetic context significantly influences the maintenance and evolution of degenerate pathways.
Bruger EL, Chubiz LM, Rojas Echenique JI, Renshaw CJ, Espericueta V, Draghi JA, Marx CJ. Genetic context significantly influences the maintenance and evolution of degenerate pathways. Genome Biology and Evolution. 13 (2021). [pdf] doi.org/10.1093/gbe/evab082
Methylothon
Ceci Martinez-Gomez, Jessica Lee, and I have begun a new outreach effort as part of our NSF Dimensions of Biodiversity project (). We call this the Methylothon: a multi-way competition between natural isolates of Methylobacterium collected by high school students, so far having been run…